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Literature summary for 3.4.22.39 extracted from

  • Grosche, P.; Sirockin, F.; Mac Sweeney, A.; Ramage, P.; Erbel, P.; Melkko, S.; Bernardi, A.; Hughes, N.; Ellis, D.; Combrink, K.D.; Jarousse, N.; Altmann, E.
    Structure-based design and optimization of potent inhibitors of the adenoviral protease (2015), Bioorg. Med. Chem. Lett., 25, 438-443.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
-
Human adenovirus sp.
3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
-
Human adenovirus sp.
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
-
Human adenovirus sp.
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
-
Human adenovirus sp.
N-[(2S)-2-(3,5-dichlorophenyl)-2-(ethylamino)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
-
Human adenovirus sp.
N-[(2S)-2-(3-chlorophenyl)-2-[(methylsulfonyl)amino]acetyl]-L-phenylalanyl-N-(cyanomethyl)glycinamide
-
Human adenovirus sp.
N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
-
Human adenovirus sp.
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
-
Human adenovirus sp.
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
-
Human adenovirus sp.
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
-
Human adenovirus sp.
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
-
Human adenovirus sp.

Organism

Organism UniProt Comment Textmining
Human adenovirus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-WLRGGARC(PT14)-NH2 + H2O
-
Human adenovirus sp. N-acetyl-WLRGG + ARC(PT14)-NH2
-
?

Synonyms

Synonyms Comment Organism
adenain 5
-
Human adenovirus sp.
adenain 8
-
Human adenovirus sp.
adenoviral protease
-
Human adenovirus sp.
AVP5
-
Human adenovirus sp.
AVP8
-
Human adenovirus sp.

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000001
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
0.0000001
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
0.0000002
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
0.0000006
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
0.000001
-
IC50 below 0.000001 mM, isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-[(2S)-2-(3,5-dichlorophenyl)-2-(ethylamino)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
0.000001
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. 3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
0.000001
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. 3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
0.000002
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. (2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
0.000004
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. (2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
0.000007
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
0.00001
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
0.00001
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
0.00001
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
0.00003
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
0.00004
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
0.00031
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
0.00095
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
0.0011
-
isoform AVP5, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
0.00274
-
isoform AVP8, pH and temperature not specified in the publication Human adenovirus sp. N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide