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Literature summary for 3.4.22.38 extracted from

  • Wilder, C.L.; Park, K.Y.; Keegan, P.M.; Platt, M.O.
    Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues (2011), Arch. Biochem. Biophys., 516, 52-57.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
x * 29000, non-glycosylated form, SDS-PAGE Homo sapiens
37000
-
x * 37000, glycoprotein, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
?
-
?
Gelatin + H2O Homo sapiens cathepsin K maintains activity on gelatin at pH 7.0 and 8.0 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O cathepsin K maintains activity on gelatin at pH 7.0 and 8.0 Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 29000, non-glycosylated form, SDS-PAGE Homo sapiens
? x * 37000, glycoprotein, SDS-PAGE Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
4
-
cathepsin K activity disappears when incubated at pH 4.0 instead of 6.0 Homo sapiens