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Literature summary for 3.4.22.38 extracted from

  • Quintanilla-Dieck, M.J.; Codriansky, K.; Keady, M.; Bhawan, J.; Ruenger, T.M.
    Expression and regulation of cathepsin K in skin fibroblasts (2009), Exp. Dermatol., 18, 596-602.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Homo sapiens
-
?
-
?
Collagen IV + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermis in the dermis, cathepsin K is expressed only under certain circumstances such as scarring or inflammation Homo sapiens
-
skin fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
Homo sapiens ?
-
?
Collagen IV + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
catK
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ligand of receptor activator of nuclear factor-kappaB does not induce cathepsin K expression in fibroblasts additional information
Homo sapiens in fibroblasts, interleukin-1alpha and cellular confluence upregulate cathepsin K expression up

General Information

General Information Comment Organism
physiological function cathepsin K plays a role in intracellular collagen degradation after endocytosis Homo sapiens