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Literature summary for 3.4.22.38 extracted from
- Peptidomimetic inhibitors of cathepsin K (2010), Curr. Top. Med. Chem., 10, 745-751.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-[4'-(methylsulfanyl)biphenyl-2-yl]cyclohexanecarboxamide | - |
Homo sapiens |  |
| (1R,2S)-N-(cyanomethyl)-2-[2-[4-(methylsulfanyl)phenyl]ethyl]cyclohexanecarboxamide | - |
Homo sapiens | |
| balicatib | - |
Homo sapiens | |
| benzyl [1-[(cyanomethyl)carbamoyl]cyclohexyl]carbamate | - |
Homo sapiens | |
| L-006235 | - |
Homo sapiens | |
| L-873724 | - |
Homo sapiens | |
| MK-0674 | - |
Homo sapiens | |
| MK-1256 | - |
Homo sapiens | |
| N-(1-cyanocyclopropyl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(2-hydroxypropan-2-yl)biphenyl-4-yl]ethyl]-L-leucinamide | - |
Homo sapiens | |
| N-(1-cyanocyclopropyl)-N2-[(1S)-1-[4'-[(1R)-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl]-2,2,2-trifluoroethyl]-4-fluoro-L-leucinamide | MIV-701 | Homo sapiens | |
| N-(1-cyanocyclopropyl)-N2-[(1S)-1-[4'-[(1S)-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl]-2,2,2-trifluoroethyl]-4-fluoro-L-leucinamide | - |
Homo sapiens | |
| odanacatib | - |
Homo sapiens | |
| relacatib | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Type I collagen + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cat K | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000004 | - |
relacatib | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000003 | - |
(1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-[4'-(methylsulfanyl)biphenyl-2-yl]cyclohexanecarboxamide | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000017 | - |
N-(1-cyanocyclopropyl)-N2-[(1S)-1-[4'-[(1R)-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl]-2,2,2-trifluoroethyl]-4-fluoro-L-leucinamide | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000017 | - |
(1R,2S)-N-(cyanomethyl)-2-[2-[4-(methylsulfanyl)phenyl]ethyl]cyclohexanecarboxamide | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000043 | - |
N-(1-cyanocyclopropyl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(2-hydroxypropan-2-yl)biphenyl-4-yl]ethyl]-L-leucinamide | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00001 | - |
N-(1-cyanocyclopropyl)-N2-[(1S)-1-[4'-[(1S)-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl]-2,2,2-trifluoroethyl]-4-fluoro-L-leucinamide | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000084 | - |
benzyl [1-[(cyanomethyl)carbamoyl]cyclohexyl]carbamate | pH and temperature not specified in the publication | Homo sapiens | |
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