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Literature summary for 3.4.22.38 extracted from

  • Connor, J.R.; Lepage, C.; Swift, B.A.; Yamashita, D.; Bendele, A.M.; Maul, D.; Kumar, S.
    Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis (2009), Osteoarthritis Cartilage, 17, 1236-1243.
    View publication on PubMed
Search for more literature for 3.4.22.38

Inhibitors

Inhibitors Comment Organism Structure
SB-553484 inhibits bone and cartilage degradation in vivo Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Canis lupus familiaris degradation ?
-
 ?
collagen I + H2O Canis lupus familiaris Cat K can degrade several bone matrix proteins including type I collagen during osteoclastic bone resorption ?
-
 ?
collagen II + H2O Canis lupus familiaris degradation ?
-
 ?
additional information Canis lupus familiaris cathepsin K degrades several bone and cartilage matrix components, it is playing a role in osteoarthritis, enzyme inhibition reduces the degradation process, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
 female beagle dogs
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Canis lupus familiaris
-
cartilage
-
 Canis lupus familiaris
-
chondrocyte
-
 Canis lupus familiaris
-
femorotibial joint
-
 Canis lupus familiaris
-
fibroblast synovial Canis lupus familiaris
-
osteoclast
-
 Canis lupus familiaris
-
synovium
-
 Canis lupus familiaris
-
tibia
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O degradation Canis lupus familiaris ?
-
 ?
collagen I + H2O degradation Canis lupus familiaris ?
-
 ?
collagen I + H2O Cat K can degrade several bone matrix proteins including type I collagen during osteoclastic bone resorption Canis lupus familiaris ?
-
 ?
collagen II + H2O degradation Canis lupus familiaris ?
-
 ?
Lys-Gln-Lys-Leu-Arg-4-methylcoumarin-7-amide + H2O
-
 Canis lupus familiaris Lys-Gln-Lys-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
additional information cathepsin K degrades several bone and cartilage matrix components, it is playing a role in osteoarthritis, enzyme inhibition reduces the degradation process, overview Canis lupus familiaris ?
-
 ?

Synonyms

Synonyms Comment Organism
Cat K
-
 Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Canis lupus familiaris