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Literature summary for 3.4.22.38 extracted from

  • Han, J.; Luo, T.; Gu, Y.; Li, G.; Jia, W.; Luo, M.
    Cathepsin K regulates adipocyte differentiation: possible involvement of type I collagen degradation (2009), Endocr. J., 56, 55-63.
    View publication on PubMed

Application

Application Comment Organism
pharmacology CTSK is a possible therapeutic target in the treatment of obesity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
E64 blocks adipocyte differentiation in early stages Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Mus musculus cathepsin K regulates adipocyte differentiation, possible involvement of type I collagen degradation and regulation of collagen type I expression, molecular mechanism, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell ATCC CL-173 Mus musculus
-
adipocyte CTSK is active mainly in the early stages of adipogenesis Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O cathepsin K regulates adipocyte differentiation, possible involvement of type I collagen degradation and regulation of collagen type I expression, molecular mechanism, overview Mus musculus ?
-
?
collagen I + H2O type I collagen degradation Mus musculus ?
-
?
Gelatin + H2O substrate for CTSK zymography Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
CTSK
-
Mus musculus