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Literature summary for 3.4.22.38 extracted from

  • Zhao, Q.; Jia, Y.; Xiao, Y.
    Cathepsin K: a therapeutic target for bone diseases (2009), Biochem. Biophys. Res. Commun., 380, 721-723.
    View publication on PubMed
Search for more literature for 3.4.22.38

Activating Compound

Activating Compound Comment Organism Structure
additional information retinoic acid stimulates cathepsin K expression Homo sapiens

Application

Application Comment Organism
pharmacology cathepsin K is a therapeutic target for bone diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information determination of six naturally occuring mutations in cathepsin K: an A-G transition at cDNA position 1095, a G-C transition at nucleotide 541, a C-T transition at nucleotide, a C-T transition at nucleotide 935, a G-A transition at nucleotide 236, and a T-C transition at nucleotide 926, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AAE581
-
 Homo sapiens
CID444556
-
 Homo sapiens
CRA-013783
-
 Homo sapiens
L-006235
-
 Homo sapiens
MK-0822
-
 Homo sapiens
MK-1256
-
 Homo sapiens
additional information physiological inhibitors of osteoclast differentiation and activation, such as osteoprotegerin, interleukin-6, INF-gamma, can also directly suppress cathepsin K expression Homo sapiens
N-cyano-tetrahydro-pyridazine compounds
-
 Homo sapiens
SB462595
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens important role of cathepsin K in osteoclast function, overview. The human disorder pycnodysostosis is a rare, autosomal, recessive, skeletal disorder caused by mutations in cathepsin K, the enzyme might be also involved in the pathological mechanism of osteolysis causing aseptic loosening of total hip replacement implants. In diseases such as arthritis and osteoporosis, the release of cathepsin K likely causes tissue injury. Regulation of cathepsin K expression, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cathepsin K is synthesized as an inactive pre-proenzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
osteoclast giant multinucleated cells,high expression level Homo sapiens
-
ovary
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information important role of cathepsin K in osteoclast function, overview. The human disorder pycnodysostosis is a rare, autosomal, recessive, skeletal disorder caused by mutations in cathepsin K, the enzyme might be also involved in the pathological mechanism of osteolysis causing aseptic loosening of total hip replacement implants. In diseases such as arthritis and osteoporosis, the release of cathepsin K likely causes tissue injury. Regulation of cathepsin K expression, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More cathepsin K tertiary structure, overview Homo sapiens

Synonyms

Synonyms Comment Organism
More cathepsin K is a member of the papain family of cysteine proteases Homo sapiens