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Literature summary for 3.4.22.38 extracted from

  • Brömme, D.; Okamoto, K.; Wang, B.B.; Biroc, S.
    Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts (1996), J. Biol. Chem., 271, 2126-2132.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Benzyloxycarbonyl-Phe-Ala-CHN2
-
Homo sapiens
Benzyloxycarbonyl-Phe-Phe-CHN2
-
Homo sapiens
calpeptin
-
Homo sapiens
chicken cystatin
-
Homo sapiens
chymostatin
-
Homo sapiens
iodoacetate
-
Homo sapiens
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.0038
-
benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.0075
-
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.0131
-
Benzyloxycarbonyl-Val-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.0185
-
Benzyloxycarbonyl-Val-Val-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.023
-
benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
mature cathepsin O2, SDS-PAGE Homo sapiens
43000
-
precursor cathepsin O2, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
expressed in Sf9 cells with Autographa californica nuclear polyhedrosis virus
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
cathepsin O2 precursor, which can be processed to mature enzyme at 4 C Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O
-
Homo sapiens Benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
?
Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
Homo sapiens Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
?
Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
Homo sapiens Benzyloxycarbonyl-Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
?
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
Homo sapiens Benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?
Benzyloxycarbonyl-Val-Arg 4-methylcoumarin 7-amide + H2O
-
Homo sapiens Benzyloxycarbonyl-Val-Arg + 7-amino-4-methylcoumarin
-
?
Benzyloxycarbonyl-Val-Val-Arg 4-methylcoumarin 7-amide + H2O
-
Homo sapiens Benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
?
Collagen type I + H2O
-
Homo sapiens Fragemnts of collagen type I cleavage in telopeptide region ?

Subunits

Subunits Comment Organism
monomer 1 * 43000, precursor cathepsin O2, SDS-PAGE Homo sapiens
monomer 1 * 29000, mature cathepsin O2, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0005
-
benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.01
-
Benzyloxycarbonyl-Val-Val-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.02
-
Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.9
-
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
0.98
-
benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide
-
Homo sapiens
1.06
-
Benzyloxycarbonyl-Val-Arg 4-methylcoumarin 7-amide
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4 8 less than 50% of maximal activity above and below Homo sapiens