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Literature summary for 3.4.22.37 extracted from

  • Taniguchi, M.; Matsuhashi, Y.; Abe, T.K.; Ishiyama, Y.; Saitoh, E.; Kato, T.; Ochiai, A.; Tanaka, T.
    Contribution of cationic amino acids toward the inhibition of Arg-specific cysteine proteinase (Arg-gingipain) by the antimicrobial dodecapeptide, CL(14-25), from rice protein (2014), Biopolymers, 102, 379-389.
    View publication on PubMed
Search for more literature for 3.4.22.37

Inhibitors

Inhibitors Comment Organism Structure
RLMAAKAESRK competitive inhibitor Porphyromonas gingivalis
RRLMAAKAES mixed-type inhibitor Porphyromonas gingivalis
RRLMAAKAESR mixed-type inhibitor Porphyromonas gingivalis
RRLMAAKAESRK mixed-type inhibitor, the arginine residue at position 15 of the docapeptide substantially contributes to the enzyme-inhibitory activity and the arginine residue at position 14 plays important roles in exerting enzyme-inhibitory activity Porphyromonas gingivalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0044
-
 Z-Phe-Arg-7-amido-4-methylcoumarin at pH 7.5 and 37°C Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis B2RKK0
-
-
Porphyromonas gingivalis ATCC 33277 B2RKK0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Porphyromonas gingivalis Z-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Porphyromonas gingivalis ATCC 33277 Z-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
Arg-specific cysteine proteinase
-
 Porphyromonas gingivalis
RGP
-
 Porphyromonas gingivalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00096
-
 RRLMAAKAESRK at pH 7.5 and 37°C Porphyromonas gingivalis
0.0013
-
 RRLMAAKAESR at pH 7.5 and 37°C Porphyromonas gingivalis
0.0013
-
 RRLMAAKAES at pH 7.5 and 37°C Porphyromonas gingivalis
0.0099
-
 RLMAAKAESRK at pH 7.5 and 37°C Porphyromonas gingivalis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.145
-
 at pH 7.5 and 37°C Porphyromonas gingivalis RRLMAAKAESRK
0.242
-
 at pH 7.5 and 37°C Porphyromonas gingivalis RRLMAAKAESR
0.248
-
 at pH 7.5 and 37°C Porphyromonas gingivalis RLMAAKAESRK