Any feedback?
Literature summary for 3.4.22.37 extracted from
- Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains (2009), Microbiology, 155, 3238-3246.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protease-activated receptor-1 + H2O | Porphyromonas gingivalis | specific substrate for Arg-gingipain | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protease-activated receptor-1 + H2O | specific substrate for Arg-gingipain | Porphyromonas gingivalis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Arg-gingipain | - |
Porphyromonas gingivalis |
| RGP | - |
Porphyromonas gingivalis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | human keratinocyte Rgp-deficient and Kgp-deficient double mutant cells do not cleave protease-activated recptor-1 and -2. The single Rgp-negative mutant cleaves protease-activated recptor-2 | Porphyromonas gingivalis |
| physiological function | Rgp-cleavage of protease-activated receptor-1 up-regulates expression of cytokines | Porphyromonas gingivalis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
