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Literature summary for 3.4.22.37 extracted from

  • Monteiro, A.C.; Scovino, A.; Raposo, S.; Gaze, V.M.; Cruz, C.; Svensjoe, E.; Narciso, M.S.; Colombo, A.P.; Pesquero, J.B.; Feres-Filho, E.; Nguyen, K.A.; Sroka, A.; Potempa, J.; Scharfstein, J.
    Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis (2009), J. Immunol., 183, 3700-3711.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
D-Phe-Pro-Arg-chloromethyl ketone Porphyromonas gingivalis treated with gingipain inhibitor do not induce buccal edema and gingivitis in BALB/c or C57BL/6 mice Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
Arg-gingipain A
-
 Porphyromonas gingivalis
RgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis

General Information

General Information Comment Organism
malfunction Porphyromonas gingivalis RgpA/B double mutant do not induce buccal edema and gingivitis in BALB/c or C57BL/6 mice Porphyromonas gingivalis
physiological function Porphyromonas gingivalis W83 (wild type), but not gingipain-deficient mutant or wild-type bacteria pretreated with gingipain inhibitors, elicit buccal edema and gingivitis in BALB/c or C57BL/6 mice. Studies in Toll-like receptors 2-/-, bradykinin B2 receptor -/-, and neutrophil-depleted C57BL/6 mice reveal that Porphyromonas gingivalis induce edema through the sequential activation of Toll-like receptors 2/neutrophils, with the initial plasma leakage being amplified by gingipain-dependent release of vasoactive kinins from plasma-borne kininogens Porphyromonas gingivalis