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Literature summary for 3.4.22.37 extracted from
- Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment (2009), Infect. Immun., 77, 4761-4770.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vesicle | Porphyromonas gingivalis secretes outer membrane vesicles that contain major virulence factors, including Arg-gingipain and Lys-gingipain | Porphyromonas gingivalis | 31982 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| transferring receptor + H2O | Porphyromonas gingivalis | Rgp is responsible for transferring receptor degradation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| transferring receptor + H2O | Rgp is responsible for transferring receptor degradation | Porphyromonas gingivalis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Arg-gingipain | - |
Porphyromonas gingivalis |
| RGP | - |
Porphyromonas gingivalis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Porphyromonas gingivalis secretes outer membrane vesicles that contain major virulence factors, including Arg-gingipain and Lys-gingipain. Proteolytic activity of Rgp is required for membrane vesicles entry. Only few Rgp-null membrane vesicles enter the cells, and these negligibly degrade transferrin receptor, whereas paxillin and focal adhesion kinase degradation is significant | Porphyromonas gingivalis |
| physiological function | following entry of Porphyromonas gingivalis membrane vesicles into host cells, membrane vesicle-associated gingipains degrade cellular functional molecules such as transferrin receptor and paxillin/FAK, resulting in cellular impairment, indicating that Porphyromonas gingivalis membrane vesicles are potent vehicles for transmission of virulence factors into host cells | Porphyromonas gingivalis |
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