Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
elafin + H2O | Porphyromonas gingivalis | all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) | ? | - |
? | |
elafin + H2O | Porphyromonas gingivalis | all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) with RgpB being far more efficient than other gingipains. RgpB efficiently inactivates the inhibitory activity of elafin at subnanomolar concentrations through proteolysis limited to the Arg22-Cys23 peptide bond within the surface loop harboring the inhibitor active site | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | P28784 | - |
- |
Porphyromonas gingivalis | P95493 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
elafin + H2O | all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) | Porphyromonas gingivalis | ? | - |
? | |
elafin + H2O | all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) with RgpB being far more efficient than other gingipains. RgpB efficiently inactivates the inhibitory activity of elafin at subnanomolar concentrations through proteolysis limited to the Arg22-Cys23 peptide bond within the surface loop harboring the inhibitor active site | Porphyromonas gingivalis | ? | - |
? | |
MeoSuc-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Porphyromonas gingivalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Arg-gingipain | - |
Porphyromonas gingivalis |
HRgpA | - |
Porphyromonas gingivalis |
RgpB | - |
Porphyromonas gingivalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Porphyromonas gingivalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Porphyromonas gingivalis |