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Literature summary for 3.4.22.37 extracted from

  • Stathopoulou, P.G.; Benakanakere, M.R.; Galicia, J.C.; Kinane, D.F.
    The host cytokine response to Porphyromonas gingivalis is modified by gingipains (2009), Oral Microbiol. Immunol., 24, 11-17.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Protein Variants

Protein Variants Comment Organism
additional information gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
leupeptin a specific arginine-gingipain inhibitor Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
interleukin-1beta + H2O Porphyromonas gingivalis biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain, EC 3.4.22.47 ?
-
 ?
interleukin-6 + H2O Porphyromonas gingivalis biological inactivation and degradation ?
-
 ?
interleukin-8 + H2O Porphyromonas gingivalis biological inactivation and degradation ?
-
 ?
additional information Porphyromonas gingivalis extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 strains ATCC33277 and W50/ATCC 53978
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
interleukin-1beta + H2O low activity Porphyromonas gingivalis ?
-
 ?
interleukin-1beta + H2O biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain, EC 3.4.22.47 Porphyromonas gingivalis ?
-
 ?
interleukin-6 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
interleukin-6 + H2O biological inactivation and degradation Porphyromonas gingivalis ?
-
 ?
interleukin-8 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
interleukin-8 + H2O biological inactivation and degradation Porphyromonas gingivalis ?
-
 ?
additional information extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis Porphyromonas gingivalis ?
-
 ?
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-alpha-benzoyl-DL-arginine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
arginine-gingipain
-
 Porphyromonas gingivalis
RGP
-
 Porphyromonas gingivalis
RgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Porphyromonas gingivalis