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Literature summary for 3.4.22.37 extracted from

  • Sheets, S.M.; Potempa, J.; Travis, J.; Fletcher, H.M.; Casiano, C.A.
    Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis (2006), Infect. Immun., 74, 5667-5678.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Inhibitors

Inhibitors Comment Organism Structure
Nalpha-p-tosyl-L-lysine chloromethyl ketone TLCK Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cell adhesion molecule + H2O Porphyromonas gingivalis involved in the detachment of endothelial cells ?
-
 ?
additional information Porphyromonas gingivalis involved in the induction of apoptosis in caspase dependent and caspase independent pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 strains W83 and HG66
-

Purification (Commentary)

Purification (Comment) Organism
-
 Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cell adhesion molecule + H2O involved in the detachment of endothelial cells Porphyromonas gingivalis ?
-
 ?
additional information involved in the induction of apoptosis in caspase dependent and caspase independent pathway Porphyromonas gingivalis ?
-
 ?
N-alpha-benzoyl-D,L-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-alpha-benzoyl-L-arginine + 4-nitroaniline
-
 ?
N-cadherin + H2O in BCAEC cells, cleavage by HRgpA but not RgpB Porphyromonas gingivalis ?
-
 ?
VE-cadherin + H2O in BCAEC cells, especially HRgpA Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
HRgpA isoform encoded by the rgpA gene Porphyromonas gingivalis
HrgpB isoform encoded by the rgpB gene Porphyromonas gingivalis
mt-RgpA membrane type of enzyme, isoform encoded by the rgpA gene Porphyromonas gingivalis
mt-RgpB isoform encoded by the rgpB gene Porphyromonas gingivalis
RgpA
-
 Porphyromonas gingivalis
RgpA(cat) isoform encoded by the rgpA gene Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis