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Literature summary for 3.4.22.37 extracted from

  • Yun, L.W.; Decarlo, A.A.; Hunter, N.
    Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis (2007), Clin. Exp. Immunol., 150, 217-229.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Inhibitors

Inhibitors Comment Organism Structure
N-alpha-tosyl-L-lysyl chloromethyl ketone TLCK Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CD27 protein + H2O Porphyromonas gingivalis involved in reduction of T-cell function, effective even in the presence of 2.5 or 5% serum ?
-
 ?
additional information Porphyromonas gingivalis important virulence factors in periodontitis, probably involved in the reduction of T-cell function at periodontal lesion sites, induction of PAR-1 and PAR-2 receptor expression, up-regulation of PAR-4 expression, little effect on PAR-3 expression, increases expression of CD69 and CD25 on T-cells ?
-
 ?
additional information Porphyromonas gingivalis no degradation of ICAM-3 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 strain ATCC 33277
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD27 protein + H2O involved in reduction of T-cell function, effective even in the presence of 2.5 or 5% serum Porphyromonas gingivalis ?
-
 ?
additional information important virulence factors in periodontitis, probably involved in the reduction of T-cell function at periodontal lesion sites, induction of PAR-1 and PAR-2 receptor expression, up-regulation of PAR-4 expression, little effect on PAR-3 expression, increases expression of CD69 and CD25 on T-cells Porphyromonas gingivalis ?
-
 ?
additional information no degradation of ICAM-3 Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
RgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis