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Literature summary for 3.4.22.37 extracted from

  • Bialas, A.; Grembecka, J.; Krowarsch, D.; Otlewski, J.; Potempa, J.; Mucha, A.
    Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity (2006), J. Med. Chem., 49, 1744-1753.
    View publication on PubMed
Search for more literature for 3.4.22.37

Activating Compound

Activating Compound Comment Organism Structure
cysteine activates Porphyromonas gingivalis

Application

Application Comment Organism
medicine development of structure-based inhibitors for treatment of periodontal diseases Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
Chloromethyl ketones development of several inhibitor derivatives: structure-based design, chemistry, and activity, specificity for the Sn binding pocket of the enzyme, overview Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Porphyromonas gingivalis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis gingipains are essential for bacterial virulence and survival ?
-
 ?
additional information Porphyromonas gingivalis HG66 gingipains are essential for bacterial virulence and survival ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis HG66
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native extracellular enzyme from culture medium Porphyromonas gingivalis

Reaction

Reaction Comment Organism Reaction ID
hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 active site structure, role of the Sn binding pocket, molecular basis for substrate specificity Porphyromonas gingivalis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information gingipains are essential for bacterial virulence and survival Porphyromonas gingivalis ?
-
 ?
additional information role of the Sn binding pocket, molecular basis for substrate specificity, overview Porphyromonas gingivalis ?
-
 ?
additional information gingipains are essential for bacterial virulence and survival Porphyromonas gingivalis HG66 ?
-
 ?
additional information role of the Sn binding pocket, molecular basis for substrate specificity, overview Porphyromonas gingivalis HG66 ?
-
 ?
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-p-tosyl-Gly-Pro-Arg + 4-nitroaniline
-
 ?
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O
-
 Porphyromonas gingivalis HG66 N-p-tosyl-Gly-Pro-Arg + 4-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
More crystal structure analysis Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
RGP
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Porphyromonas gingivalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, overview Porphyromonas gingivalis