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Literature summary for 3.4.22.37 extracted from

  • Liu, X.; Sroka, A.; Potempa, J.; Genco, C.A.
    Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR (2004), Biol. Chem., 385, 1049-1057.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene rgpA, expression analysis and regulation Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
haptoglobin + H2O Porphyromonas gingivalis degradation of host protein substrate ?
-
 ?
Hemoglobin + H2O Porphyromonas gingivalis degradation of host protein substrate ?
-
 ?
hemopexin + H2O Porphyromonas gingivalis degradation of host protein substrate ?
-
 ?
additional information Porphyromonas gingivalis the enzyme degrades host iron- and heme-containing proteins, regulation of enzyme expression, overview, inhibition of gingipain increases the hmuR gene expression encoding the heme/hemoglobin receptor HmuR, and decreases the cell growth in the early and middle stages, but not in the late stages ?
-
 ?
transferrin + H2O Porphyromonas gingivalis degradation of host protein substrate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 gene rgpA, encoding enzyme RgpA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
haptoglobin + H2O degradation of host protein substrate Porphyromonas gingivalis ?
-
 ?
Hemoglobin + H2O degradation of host protein substrate Porphyromonas gingivalis ?
-
 ?
hemopexin + H2O degradation of host protein substrate Porphyromonas gingivalis ?
-
 ?
additional information the enzyme degrades host iron- and heme-containing proteins, regulation of enzyme expression, overview, inhibition of gingipain increases the hmuR gene expression encoding the heme/hemoglobin receptor HmuR, and decreases the cell growth in the early and middle stages, but not in the late stages Porphyromonas gingivalis ?
-
 ?
transferrin + H2O degradation of host protein substrate Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
arginine-specific gingipain proteinase
-
 Porphyromonas gingivalis
RgpA
-
 Porphyromonas gingivalis