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Literature summary for 3.4.22.37 extracted from

  • Smalley, J.W.; Thomas, M.F.; Birss, A.J.; Withnall, R.; Silver, J.
    A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin (2004), Biochem. J., 379, 833-840.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Protein Variants

Protein Variants Comment Organism
additional information strain W501 is deficient for RgpA, strain E8 for Rgp, and strain D7 for RgpB Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
leupeptin inhibits Arg-specific Rgp, but not Lys-specific Kgp Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis a combination of both arginine- and lysine-specific gingipain activity is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin, interaction with oxyhemoglobin, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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 wild-type strain W50, and enzyme-deficient strains D7, W501, and E8, genes rgpA and rgpB
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a combination of both arginine- and lysine-specific gingipain activity is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin, interaction with oxyhemoglobin, overview Porphyromonas gingivalis ?
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 ?
N-alpha-benzoyl-DL-Arg-4-nitroanilide + H2O
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 Porphyromonas gingivalis N-alpha-benzoyl-DL-Arg + 4-nitroaniline
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 ?
N-alpha-benzoyl-DL-Lys-4-nitroanilide + H2O
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 Porphyromonas gingivalis N-alpha-benzoyl-DL-Lys + 4-nitroaniline
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 ?

Synonyms

Synonyms Comment Organism
Arginine-specific gingipain
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 Porphyromonas gingivalis
RgpA
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 Porphyromonas gingivalis
RgpB
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 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Porphyromonas gingivalis