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Literature summary for 3.4.22.36 extracted from

  • Puri, A.W.; Broz, P.; Shen, A.; Monack, D.M.; Bogyo, M.
    Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection (2012), Nat. Chem. Biol., 8, 745-747.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Protein Variants

Protein Variants Comment Organism
C284A inactive Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AWP28
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Mus musculus
-
 interleukin-1beta propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
 Mus musculus interleukin-1beta propeptide
-
 ?

Synonyms

Synonyms Comment Organism
Casp1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction apoptosis is triggered upon bacterial infection in primary murine bone marrow macrophages lacking caspase-1 Mus musculus
physiological function upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of pro-inflammatory pyroptotic cell death Mus musculus