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Literature summary for 3.4.22.36 extracted from

  • Heymann, M.C.; Winkler, S.; Luksch, H.; Flecks, S.; Franke, M.; Russ, S.; Ozen, S.; Yilmaz, E.; Klein, C.; Kallinich, T.; Lindemann, D.; Brenner, S.; Ganser, G.; Roesler, J.; Roesen-Wolff, A.; Hofmann, S.R.
    Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-kappaB signaling (2014), J. Immunol., 192, 4379-4385.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A329T a procaspase-1 variant with decreased enzymatic activity Homo sapiens
C285A a procaspase-1 variant with decreased enzymatic activity showing about 3.5fold increased nuclear factor-kappaB activation compared to the wild type enzyme Homo sapiens
K319R a procaspase-1 variant with decreased enzymatic activity showing about 1.6fold increased nuclear factor-kappaB activation compared to the wild type enzyme Homo sapiens
L265S a procaspase-1 variant with decreased enzymatic activity showing about 6.5fold increased nuclear factor-kappaB activation compared to the wild type enzyme Homo sapiens
N263S a procaspase-1 variant with decreased enzymatic activity showing about 1.8fold increased nuclear factor-kappaB activation compared to the wild type enzyme Homo sapiens
R221C a procaspase-1 variant with decreased enzymatic activity Homo sapiens
R240Q a procaspase-1 variant with decreased enzymatic activity showing about 5fold increased nuclear factor-kappaB activation compared to the wild type enzyme Homo sapiens
T267I a procaspase-1 variant with decreased enzymatic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CrmA protein
-
Homo sapiens
Z-Val-Ala-Asp-fluoromethylketone
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
interleukin-1beta propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
Homo sapiens interleukin-1beta propeptide
-
?

Synonyms

Synonyms Comment Organism
Casp1
-
Homo sapiens
procaspase-1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via receptor interacting protein kinase 2 and nuclear factor-kappaB signaling Homo sapiens