Protein Variants | Comment | Organism |
---|---|---|
A329T | a procaspase-1 variant with decreased enzymatic activity | Homo sapiens |
C285A | a procaspase-1 variant with decreased enzymatic activity showing about 3.5fold increased nuclear factor-kappaB activation compared to the wild type enzyme | Homo sapiens |
K319R | a procaspase-1 variant with decreased enzymatic activity showing about 1.6fold increased nuclear factor-kappaB activation compared to the wild type enzyme | Homo sapiens |
L265S | a procaspase-1 variant with decreased enzymatic activity showing about 6.5fold increased nuclear factor-kappaB activation compared to the wild type enzyme | Homo sapiens |
N263S | a procaspase-1 variant with decreased enzymatic activity showing about 1.8fold increased nuclear factor-kappaB activation compared to the wild type enzyme | Homo sapiens |
R221C | a procaspase-1 variant with decreased enzymatic activity | Homo sapiens |
R240Q | a procaspase-1 variant with decreased enzymatic activity showing about 5fold increased nuclear factor-kappaB activation compared to the wild type enzyme | Homo sapiens |
T267I | a procaspase-1 variant with decreased enzymatic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CrmA protein | - |
Homo sapiens | |
Z-Val-Ala-Asp-fluoromethylketone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | Homo sapiens | - |
interleukin-1beta propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | - |
Homo sapiens | interleukin-1beta propeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Casp1 | - |
Homo sapiens |
procaspase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via receptor interacting protein kinase 2 and nuclear factor-kappaB signaling | Homo sapiens |