Literature summary for 3.4.22.36 extracted from

Kang, T.J.; Lee, G.S.; Kim, S.K.; Jin, S.H.; Chae, G.T.
Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium leprae infection (2010), Mediators Inflamm., 2010, 708713.

Search for more literature for 3.4.22.36

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	mutant mouse bearing amino acid differences in Naip5, one of the NOD-like receptors (NLRs), one of the adaptor proteins for caspase-1 activation	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
caspase-1	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	macrophages from A/J mice exhibit reduced caspase-1 activation and IL-1beta secretion compared to C57BL/6 macrophages	down

General Information

General Information	Comment	Organism
malfunction	infection with Mycobacterium leprae induces high levels of TNF-alpha production and NF-kappaB activation in macrophages of A/J mice (mutant mouse bearing amino acid differences in Naip5, one of the NOD-like receptors (NLRs), one of the adaptor proteins for caspase-1 activation) and C57BL/6 macrophages. Caspase-1 activation and IL-1beta secretion are also induced in both macrophages. Macrophages from A/J mice exhibit reduced caspase-1 activation and IL-1beta secretion compared to C57BL/6 macrophages	Mus musculus

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Release 2023.1 (January 2023)