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Literature summary for 3.4.22.36 extracted from

  • Weigert, A.; Cremer, S.; Schmidt, M.V.; von Knethen, A.; Angioni, C.; Geisslinger, G.; Bruene, B.
    Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells (2010), Blood, 115, 3531-3540.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ac-YVAD-chloromethylketone inhibition of caspase-1 with Ac-YVAD-CMK prevents SphK2 cleavage Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingosine kinase 2 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine kinase 2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
caspase-1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction release of truncated SphK2 into the supernatant is attenuated in caspase-1 knockdown cells Homo sapiens
physiological function during cell death, sphingosine kinase 2 (SphK2) is cleaved at its N-terminus in a caspase-1-dependent manner. A truncated but enzymatically active fragment of SphK2 is released from cells Homo sapiens