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Literature summary for 3.4.22.36 extracted from

  • Shen, J.; Yin, Y.; Mai, J.; Xiong, X.; Pansuria, M.; Liu, J.; Maley, E.; Saqib, N.U.; Wang, H.; Yang, X.F.
    Caspase-1 recognizes extended cleavage sites in its natural substrates (2010), Atherosclerosis, 210, 422-429.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ataxin-3 + H2O
-
Homo sapiens ?
-
?
Bcl-xL + H2O
-
Homo sapiens ?
-
?
beta-actin + H2O
-
Homo sapiens ?
-
?
calpastatin + H2O
-
Homo sapiens ?
-
?
caspase-1 + H2O
-
Homo sapiens ?
-
?
GADPH + H2O
-
Homo sapiens ?
-
?
HnRNP + H2O
-
Homo sapiens ?
-
?
Hsp90 + H2O
-
Homo sapiens ?
-
?
IL-1 beta + H2O
-
Homo sapiens ?
-
?
IL-18 + H2O
-
Homo sapiens ?
-
?
IL1F7 + H2O
-
Homo sapiens ?
-
?
LMNA Isoform + H2O
-
Homo sapiens ?
-
?
MAP-tau Isoform + H2O
-
Homo sapiens ?
-
?
additional information caspase-1 and caspase-9 share 100% aspartic acid in the P1 position. The structures in the cleavage sites of most caspase-1 substrates are different from that of caspase-9 substrates in the following three aspects, 1. the amino acid residues with the statistically high frequencies 2. the hydrophobic amino acid occurrence frequencies and 3. the charged amino acid occurrence frequencies, second, the amino acid pairs P1-P1' are different Homo sapiens ?
-
?
Nedd4 + H2O
-
Homo sapiens ?
-
?
parkin + H2O
-
Homo sapiens ?
-
?
PARP + H2O
-
Homo sapiens ?
-
?
PLA2G4A + H2O
-
Homo sapiens ?
-
?
PPARgamma + H2O
-
Homo sapiens ?
-
?
PSEN1 + H2O
-
Homo sapiens ?
-
?
PSEN2 + H2O
-
Homo sapiens ?
-
?
pyrin + H2O
-
Homo sapiens ?
-
?
SPTAN1 + H2O
-
Homo sapiens ?
-
?
TF AP-2alpha + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
caspase-1
-
Homo sapiens