Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | Mus musculus | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
peritoneal macrophage | CD8+ | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | - |
Mus musculus | mature interleukin-1beta + ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Mus musculus | caspase-1 is upregulated in CD8+ cells with decreased expression of interleukin-4 and interleukin-10 | down |
General Information | Comment | Organism |
---|---|---|
physiological function | the role of caspase-1 in inducing the CD4+ T cell activity increases with interleukin-18 rather than CD8+ suppressor cell activity. There is a selective deletion of T lymphocytes mediated by caspase-1 via interleukin-18 | Mus musculus |