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Literature summary for 3.4.22.36 extracted from

  • Terada, K.; Yamada, J.; Hayashi, Y.; Wu, Z.; Uchiyama, Y.; Peters, C.; Nakanishi, H.
    Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia (2010), Glia, 58, 114-124.
    View publication on PubMed
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
cathepsin B cathepsin B can effectively cleave and activate pro-caspase-1 in a cell-free system only at an acidic pH and in THP-1 monocytic cells after stimulation with the microbial toxin nigericin Mus musculus
chromogranin A chromogranin A can activate pro-caspase-1 in microglia Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CA-074Me the caspase-1 activation is inhibited by CA-074Me, marked inhibition at 0.05 mM Mus musculus
E-64d the caspase-1 activation is inhibited by E-64d, marked inhibition at 0.05 mM Mus musculus
Z-L-Tyr-L-Val-L-Ala-L-Asp-fluoromethylketone specific inhibitor for caspase-1, complete inhibition at 0.05 mM Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
microglia
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
 Mus musculus mature interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus C57/Bl mature interleukin-1beta + ?
-
 ?