Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-Tyr-L-Val-L-Ala-L-Asp-CHO | caspase-1-specific inhibitor | Homo sapiens | |
additional information | caspase-1 is not inhibited by Asp-Glu-Val-Asp-CHO, Ile-Glu-Thr-Asp-CHO, and Leu-Glu-His-Asp-CHO | Homo sapiens | |
YN-1234 | i.e. N-2-naphthoyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-prolinamide | Homo sapiens | |
Z-L-Val-L-Ala-L-Asp-fluoromethylketone | broad-spectrum caspase inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | Homo sapiens | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | caspase-1 activity is not detected in Jurkat cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-YVAD-4-nitroanilide + H2O | - |
Homo sapiens | acetyl-YVAD + 4-nitroaniline | - |
? | |
pro-interleukin-1beta + H2O | - |
Homo sapiens | mature interleukin-1beta + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ICE | - |
Homo sapiens |
interleukin converting enzyme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
- |
Homo sapiens | L-Tyr-L-Val-L-Ala-L-Asp-CHO | |
0.000024 | - |
- |
Homo sapiens | YN-1234 |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase-1 is mainly involved in cytokine maturation, leading to an inflammatory response | Homo sapiens |