Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.36 extracted from

  • Boxer, M.B.; Quinn, A.M.; Shen, M.; Jadhav, A.; Leister, W.; Simeonov, A.; Auld, D.S.; Thomas, C.J.
    A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety (2010), ChemMedChem, 5, 730-738.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
acetyl-L-Leu-L-Glu-L-His-L-Asp-CHO
-
 Homo sapiens
IDN-6556 active-site inhibitor that acts through irreversible covalent modification of the catalytic cysteine residue Homo sapiens
L-Tyr-L-Val-L-Ala-L-Asp-CN
-
 Homo sapiens
NCGC00183434 i.e. (S)-3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoic acid, competitive inhibition Homo sapiens
NCGC00183681 i.e. (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((S)-1-cyano-2-(1H-tetrazol-5-yl)ethyl)pyrrolidine-2-carboxamide Homo sapiens
NCGC00185682 i.e. 3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoate Homo sapiens
pralnacasan VX-740, active-site inhibitor that acts through reversible covalent modification of the catalytic cysteine residue Homo sapiens
VRT-043198
-
 Homo sapiens
VX-765
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
 mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Z-LEHD)2-R110 tetrapeptide + H2O
-
 Homo sapiens ?
-
 ?
acetyl-L-Leu-L-Glu-L-His-L-Asp-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens acetyl-L-Leu-L-Glu-L-His-L-Asp + 7-amino-4-methylcoumarin
-
 ?
pro-interleukin-1beta + H2O
-
 Homo sapiens mature interleukin-1beta + ?
-
 ?

Synonyms

Synonyms Comment Organism
ICE
-
 Homo sapiens
interleukin-converting enzyme
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000004
-
 NCGC00183434 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000000023
-
 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens NCGC00183434
0.000000204
-
 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens VRT-043198
0.00000258
-
 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens NCGC00183681
0.000015
-
 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens acetyl-L-Leu-L-Glu-L-His-L-Asp-CHO
0.0000216
-
 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens L-Tyr-L-Val-L-Ala-L-Asp-CN
0.0000434
-
 in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin Homo sapiens NCGC00185682

General Information

General Information Comment Organism
physiological function caspase 1 is a major regulator of the inflammation response Homo sapiens