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Literature summary for 3.4.22.36 extracted from
- The activity of caspase-1 is increased in lesional psoriatic epidermis (2007), J. Invest. Dermatol., 127, 2857-2864.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | anisomycin-induced activation of preformed pro-interleukin-18 is mediated by a p38 MAPK/caspase-1-dependent mechanism, whereas anisomycin-induced new synthesis of pro-interleukin-18 mRNA is mediated through p38 MAPK-dependent but caspase-1 independent mechanism | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keratinocyte | - |
Homo sapiens | - |
| skin | caspase-1 is increased in lesional psoriatic skin capared with non-lesional psoriatic skin | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | anisomycin-induced activation of preformed pro-interleukin-18 is mediated by a p38 MAPK/caspase-1-dependent mechanism, whereas anisomycin-induced new synthesis of pro-interleukin-18 mRNA is mediated through p38 MAPK-dependent but caspase-1 independent mechanism | Homo sapiens | ? | - |
? | |
| Trp-Glu-His-Asp-p-nitroanilide + H2O | - |
Homo sapiens | Trp-Glu-His-Asp + p-nitroaniline | - |
? | |
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