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Literature summary for 3.4.22.36 extracted from

  • Muehlbauer, S.M.; Evering, T.H.; Bonuccelli, G.; Squires, R.C.; Ashton, A.W.; Porcelli, S.A.; Lisanti, M.P.; Brojatsch, J.
    Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis (2007), Cell Cycle, 6, 758-766.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Tyr-Val-Ala-Asp-chloromethylketone
-
Mus musculus
benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone
-
Mus musculus
butyloxycarbonyl-Asp-chloromethylketone
-
Mus musculus
butyloxycarbonyl-Asp-fluoromethylketone
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression in anthrax lethal toxin-treated BALB/c mice ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression in anthrax lethal toxin-treated BALB/c mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression in anthrax lethal toxin-treated BALB/c mice Mus musculus ?
-
?