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Literature summary for 3.4.22.36 extracted from

  • Young, J.L.; Sukhova, G.K.; Foster, D.; Kisiel, W.; Libby, P.; Schonbeck, U.
    The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells (2000), J. Exp. Med., 191, 1535-1544.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
serpin proteinase inhibitor 9 endogenous inhibitor of caspase-1 activity in human vascular smooth muscle cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pre-interleukin-18 + H2O Homo sapiens caspase-1 regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin-1beta and IL18 or mediating apoptotic processes interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O Homo sapiens caspase-1 regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin-1beta and IL18 or mediating apoptotic processes 17000 Da fragment + 28000 Da fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-interleukin-18 + H2O
-
 Homo sapiens interleukin-18 + ?
-
 ?
pre-interleukin-18 + H2O caspase-1 regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin-1beta and IL18 or mediating apoptotic processes Homo sapiens interleukin-18 + ?
-
 ?
pre-interleukin-1beta + H2O
-
 Homo sapiens 17000 Da fragment + 28000 Da fragment
-
 ?
pro-interleukin-1beta + H2O caspase-1 regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin-1beta and IL18 or mediating apoptotic processes Homo sapiens 17000 Da fragment + 28000 Da fragment
-
 ?