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Literature summary for 3.4.22.35 extracted from

  • Lidell, M.E.; Moncada, D.M.; Chadee, K.; Hansson, G.C.
    Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel (2006), Proc. Natl. Acad. Sci. USA, 103, 9298-9303.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.35

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Entamoeba histolytica
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
MUC2 mucin + H2O Entamoeba histolytica disruption of the protective mucin layer of targeted host cells, entry mechanism of the pathogen, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
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-
-

Reaction

Reaction Comment Organism Reaction ID
hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec cleavage mechanism on mucin substrate, overview Entamoeba histolytica
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MUC2 mucin + H2O disruption of the protective mucin layer of targeted host cells, entry mechanism of the pathogen, overview Entamoeba histolytica ?
-
 ?
MUC2 mucin + H2O the enzyme targets two site at the C-terminal cysteine-rich domain, which is less glycosylated and exposes its peptide chain, overview Entamoeba histolytica ?
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 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Entamoeba histolytica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Entamoeba histolytica