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Literature summary for 3.4.22.35 extracted from
- Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity (2004), J. Biol. Chem., 279, 38260-38266.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | expression of ehpc1 and ehpc2 is increased in presence of E64 in E64-sensitive and E64-resistant amoebae, overview | Entamoeba histolytica |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxymercuribenzoate | E64 inhibits cell growth and is cytopathic/lethal for E64-sensitive and E64-resistant amoebae | Entamoeba histolytica |  |
| L-trans-epoxysuccinyl-(ethoxy)-Leu-3-methylbutylamide ethyl ester | i.e. E64d, inhibits cell growth and is cytopathic/lethal for E64-sensitive and E64-resistant amoebae | Entamoeba histolytica | |
| L-trans-epoxysuccinyl-Leu-4-guanidinobutylamide | i.e. E64, inhibits cell growth in E64-resistant by about 80% and is cytopathic/lethal for E64-sensitive amoebae | Entamoeba histolytica | |
| Z-Phe-Ala-diazomethylketone | E64 inhibits cell growth and is cytopathic/lethal for E64-sensitive and E64-resistant amoebae | Entamoeba histolytica | |
| Z-Phe-Phe-diazomethylketone | 25% inhibition of E64-sensitive and E64-resistant amoba growth | Entamoeba histolytica | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| trophozoite | - |
Entamoeba histolytica | - |
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