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Literature summary for 3.4.22.35 extracted from
- On the specificity of a cysteine proteinase from Entamoeba histolytica (1988), Biomed. Biochim. Acta, 47, 115-123.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Natural and synthetic inhibitors of cysteine proteinases | - |
Entamoeba histolytica |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27000 | - |
1 * 27000, Entamoeba histolytica, SDS-PAGE | Entamoeba histolytica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
virulent strain HMI:IMSS | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Entamoeba histolytica |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen type I + H2O | digestion with an initial attack at the alpha2-chain | Entamoeba histolytica | ? | - |
? |  |
| additional information | with unblocked tetrapeptides as substrates, peptidyl dipeptidase activity of the amoeba enzyme requires an arginine at the P2 position. Lysine cannot substitute for arginine | Entamoeba histolytica | ? | - |
? | |
| additional information | splits blocked and unblocked peptide analogs with 2-naphthylamide moieties, cleavability is enhanced by the presence of basic residues, such as arginine or lysine, near the acyl end of the substrate | Entamoeba histolytica | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 27000, Entamoeba histolytica, SDS-PAGE | Entamoeba histolytica |
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