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Literature summary for 3.4.22.34 extracted from

  • Solberg, R.; Smith, R.; Almloef, M.; Tewolde, E.; Nilsen, H.; Johansen, H.T.
    Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin (2015), Biol. Chem., 396, 71-80.
    View publication on PubMed
Search for more literature for 3.4.22.34

Inhibitors

Inhibitors Comment Organism Structure
atorvastatin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
 Homo sapiens ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens legumain mRNA is down-regulated in monocytes isolated from patients treated with atorvastatin down
Homo sapiens legumain expression is increased during monocyte-to-macrophage differentiation up