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Literature summary for 3.4.22.34 extracted from
- Bovine endometrial legumain and TIMP-2 regulation in response to presence of a conceptus (2009), Mol. Reprod. Dev., 76, 65-74.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | mRNAs is up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-2-Macroglobulin | proteinase inhibitor, may be a candidate for the binding of legumain as it is an agent for the removal of endopeptidases from extracellular fluids | Bos taurus | |
| cystatin E | high affinity inhibitor of legumain | Bos taurus | |
| cystatin M | high affinity inhibitor of legumain | Bos taurus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
mature form in uterine luminal fluid, determined by SDS-PAGE | Bos taurus |
| 49000 | - |
active form, determined by SDS-PAGE | Bos taurus |
| 56000 | - |
proform, determined by SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | enzyme is a protease which specifically cleaves on the carboxyl side of asparagine residues | ? | - |
? |  |
| additional information | Bos taurus | the function of legumain in the endometrium during early placentation may be through its role as an activator of protease zymogens such as progelatinase A | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q95M12 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterine endometrium | - |
Bos taurus | - |
| uterine luminal fluid | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is a protease which specifically cleaves on the carboxyl side of asparagine residues | Bos taurus | ? | - |
? | |
| additional information | the function of legumain in the endometrium during early placentation may be through its role as an activator of protease zymogens such as progelatinase A | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| legumain | - |
Bos taurus |
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Release 2023.1 (January 2023)
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