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Literature summary for 3.4.22.34 extracted from

  • Clerin, V.; Shih, H.H.; Deng, N.; Hebert, G.; Resmini, C.; Shields, K.M.; Feldman, J.L.; Winkler, A.; Albert, L.; Maganti, V.; Wong, A.; Paulsen, J.E.; Keith, J.C.; Vlasuk, G.P.; Pittman, D.D.
    Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis (2008), Atherosclerosis, 201, 53-66.
    View publication on PubMed
Search for more literature for 3.4.22.34

Application

Application Comment Organism
medicine studies on a functional role of legumain in atherogenesis Homo sapiens
medicine studies on a functional role of legumain in atherogenesis Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99538
-
-
Homo sapiens Q99538 Homo sapiens
-
Mus musculus O89017
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta lesions at the aortic sinus and in injured carotid arteries of Apolipoprotein E deficient mice, mRNA expression increases with development of atherosclerosis in the aorta Mus musculus
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corona inflamed areas in advanced human coronary atherosclerotic plaques Homo sapiens
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HUVEC cell human umbilical vascular endothelial cells (HUVECs) tested in migration/proliferation and invasion assays Homo sapiens
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macrophage M-CSF differentiated primary macrophages, in vitro expression, also detected in the culture media Homo sapiens
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macrophage of atherosclerotic aorta of aging Apolipoprotein E deficient mice, mRNA expression increases with development of atherosclerosis Mus musculus
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monocyte fluorimetric assay measuring legumain protease activity applied Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 expression determined by RT-PCR, in situ hybridization and immunohistochemical analysis, role of legumain in the pathophysiology of atherosclerosis analyzed Mus musculus
additional information
-
 expression in atherosclerotic tissues determined by RT-PCR, in situ hybridization and immunohistochemical analysis, role of legumain in the pathophysiology of atherosclerosis analyzed Homo sapiens
additional information
-
 expression in atherosclerotic tissues determined by RT-PCR, in situ hybridization and immunohistochemical analysis, role of legumain in the pathophysiology of atherosclerosis analyzed Mus musculus
additional information
-
 expression in atherosclerotic tissues determined by RT-PCR, in situ hybridization and immunohistochemical analysis, role of legumain in the pathophysiology of atherosclerosis analyzed, human monocyte legumain activity assay described, migration/proliferation and invasion assay described Homo sapiens
additional information
-
 role of legumain in the pathophysiology of atherosclerosis analyzed, human monocyte legumain activity assay described, migration/proliferation and invasion assay described Homo sapiens

Synonyms

Synonyms Comment Organism
AEP
-
 Homo sapiens
AEP
-
 Mus musculus
asparagine endopeptidase
-
 Homo sapiens
asparagine endopeptidase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 activity assay at Mus musculus