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Literature summary for 3.4.22.34 extracted from

  • Maehr, R.; Hang, H.C.; Mintern, J.D.; Kim, Y.M.; Cuvillier, A.; Nishimura, M.; Yamada, K.; Shirahama-Noda, K.; Hara-Nishimura, I.; Ploegh, H.L.
    Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice (2005), J. Immunol., 174, 7066-7074.
    View publication on PubMed
Search for more literature for 3.4.22.34

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by leupeptin Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cathepsin L + H2O Mus musculus processing/activation ?
-
 ?
additional information Mus musculus the enzyme is not required for class II MHC antigen presentation but is essential for processing of cathepsin L in mice ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J mice and class II MHC-deficient mice
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
 Mus musculus
-
splenocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cathepsin L + H2O processing/activation Mus musculus ?
-
 ?
additional information the enzyme is not required for class II MHC antigen presentation but is essential for processing of cathepsin L in mice Mus musculus ?
-
 ?
Z-Ala-Ala-Asn-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Z-Ala-Ala-Asn + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
AEP
-
 Mus musculus
asparagine endopeptidase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Mus musculus