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Literature summary for 3.4.22.34 extracted from

  • Wolk, K.; Gruetz, G.; Witte, K.; Volk, H.D.; Sabat, R.
    The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerant monocytes (2005), Genes Immun., 6, 452-456.
    View publication on PubMed
Search for more literature for 3.4.22.34

Inhibitors

Inhibitors Comment Organism Structure
asparaginyl endopeptidase inhibitor i.e. AEPi or cysteine protease inhibitor Homo sapiens
additional information the enzyme expression is reduced by lipopolysaccharide priming and in endotoxin-tolerant monocytes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme controls antigen processing performing the key step, mechanism, the enzyme expression is reduced in endotoxin-tolerant monocytes and by lipopolysaccharide priming ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte from peripheral blood, normal and endotoxin-tolerant cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme controls antigen processing performing the key step, mechanism, the enzyme expression is reduced in endotoxin-tolerant monocytes and by lipopolysaccharide priming Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Asparaginyl endopeptidase
-
 Homo sapiens