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Literature summary for 3.4.22.33 extracted from

  • Maurer, H.R.
    Bromelain: biochemistry, pharmacology and medical use (2001), Cell. Mol. Life Sci., 58, 1234-1245.
    View publication on PubMed

Application

Application Comment Organism
medicine bromelain can be used as a phytotherapy agent in several aspects, overview Ananas comosus
pharmacology use as additive to prevent lymphedema by reducing lymphocongestion, detritus, viscosity of the exsudate and stimulation of phagocytosis of associated leukocytes, use as additive for radiotherapy and surgery due to wound healing effect and reductive effect on inflammation and edema, use as additives for chemotherapy due to inhibitory effects on malignant growth of tumor cells Ananas comosus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
x * 23000, SDS-PAGE Ananas comosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ananas comosus bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview ?
-
?
protein + H2O Ananas comosus broad substrate specificity peptides
-
?

Organism

Organism UniProt Comment Textmining
Ananas comosus
-
mainly var. Cayenne
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
Ananas comosus

Source Tissue

Source Tissue Comment Organism Textmining
fruit immature Ananas comosus
-
juice
-
Ananas comosus
-
additional information bromelain is a crude extract containing a complex mixture of several components, such as different thiol-endopeptidases, phosphatases, glucosidases, peroxidases, cellulases, glycoproteins and carbohydrates, as well as several proteinase inhibitors Ananas comosus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bromelain + H2O rapid self-digestion in aqueous solution, can be prevented by addition of alpha2-macroglobulin Ananas comosus ?
-
?
casein + H2O
-
Ananas comosus ?
-
?
Gelatin + H2O
-
Ananas comosus ?
-
?
additional information bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview Ananas comosus ?
-
?
protein + H2O broad substrate specificity Ananas comosus peptides
-
?

Subunits

Subunits Comment Organism
? x * 23000, SDS-PAGE Ananas comosus

Synonyms

Synonyms Comment Organism
Bromelain
-
Ananas comosus
Bromelin
-
Ananas comosus
More c.f. stem bromelain, enzyme belongs to the papain superfamily Ananas comosus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 8
-
Ananas comosus

pI Value

Organism Comment pI Value Maximum pI Value
Ananas comosus isoelectric focusing 4.7 4.6