BRENDA - Enzyme Database
show all sequences of 3.4.22.33

Bromelain: biochemistry, pharmacology and medical use

Maurer, H.R.; Cell. Mol. Life Sci. 58, 1234-1245 (2001)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
bromelain can be used as a phytotherapy agent in several aspects, overview
Ananas comosus
pharmacology
use as additive to prevent lymphedema by reducing lymphocongestion, detritus, viscosity of the exsudate and stimulation of phagocytosis of associated leukocytes, use as additive for radiotherapy and surgery due to wound healing effect and reductive effect on inflammation and edema, use as additives for chemotherapy due to inhibitory effects on malignant growth of tumor cells
Ananas comosus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
23000
-
x * 23000, SDS-PAGE
Ananas comosus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Ananas comosus
bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview
?
-
Ananas comosus
?
protein + H2O
Ananas comosus
broad substrate specificity
peptides
-
Ananas comosus
?
Organism
Organism
UniProt
Commentary
Textmining
Ananas comosus
-
mainly var. Cayenne
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Ananas comosus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
fruit
immature
Ananas comosus
-
juice
-
Ananas comosus
-
additional information
bromelain is a crude extract containing a complex mixture of several components, such as different thiol-endopeptidases, phosphatases, glucosidases, peroxidases, cellulases, glycoproteins and carbohydrates, as well as several proteinase inhibitors
Ananas comosus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
bromelain + H2O
rapid self-digestion in aqueous solution, can be prevented by addition of alpha2-macroglobulin
650803
Ananas comosus
?
-
650803
Ananas comosus
?
casein + H2O
-
650803
Ananas comosus
?
-
650803
Ananas comosus
?
Gelatin + H2O
-
650803
Ananas comosus
?
-
650803
Ananas comosus
?
additional information
bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview
650803
Ananas comosus
?
-
650803
Ananas comosus
?
protein + H2O
broad substrate specificity
650803
Ananas comosus
peptides
-
650803
Ananas comosus
?
Subunits
Subunits
Commentary
Organism
?
x * 23000, SDS-PAGE
Ananas comosus
Synonyms
Synonyms
Commentary
Organism
Bromelain
-
Ananas comosus
Bromelin
-
Ananas comosus
More
c.f. stem bromelain, enzyme belongs to the papain superfamily
Ananas comosus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
8
-
Ananas comosus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Ananas comosus
isoelectric focusing
4.7
4.6
Application (protein specific)
Application
Commentary
Organism
medicine
bromelain can be used as a phytotherapy agent in several aspects, overview
Ananas comosus
pharmacology
use as additive to prevent lymphedema by reducing lymphocongestion, detritus, viscosity of the exsudate and stimulation of phagocytosis of associated leukocytes, use as additive for radiotherapy and surgery due to wound healing effect and reductive effect on inflammation and edema, use as additives for chemotherapy due to inhibitory effects on malignant growth of tumor cells
Ananas comosus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
23000
-
x * 23000, SDS-PAGE
Ananas comosus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Ananas comosus
bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview
?
-
Ananas comosus
?
protein + H2O
Ananas comosus
broad substrate specificity
peptides
-
Ananas comosus
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Ananas comosus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
fruit
immature
Ananas comosus
-
juice
-
Ananas comosus
-
additional information
bromelain is a crude extract containing a complex mixture of several components, such as different thiol-endopeptidases, phosphatases, glucosidases, peroxidases, cellulases, glycoproteins and carbohydrates, as well as several proteinase inhibitors
Ananas comosus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
bromelain + H2O
rapid self-digestion in aqueous solution, can be prevented by addition of alpha2-macroglobulin
650803
Ananas comosus
?
-
650803
Ananas comosus
?
casein + H2O
-
650803
Ananas comosus
?
-
650803
Ananas comosus
?
Gelatin + H2O
-
650803
Ananas comosus
?
-
650803
Ananas comosus
?
additional information
bromelain has a profound immunmodulatory effect, overview, bromelain affects blood coagulation, fibrinolysis, and platelet functions, mechanism, overview
650803
Ananas comosus
?
-
650803
Ananas comosus
?
protein + H2O
broad substrate specificity
650803
Ananas comosus
peptides
-
650803
Ananas comosus
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 23000, SDS-PAGE
Ananas comosus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
8
-
Ananas comosus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Ananas comosus
isoelectric focusing
4.7
4.6
Other publictions for EC 3.4.22.33
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752632
Misran
-
Properties of bromelain extra ...
Ananas comosus
Biocatal. Agricult. Biotechnol.
18
101095
2019
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5
-
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1
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-
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-
-
-
-
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754265
Ghensi
In vitro effect of bromelain ...
Ananas comosus
J. Craniofac. Surg.
30
1064-1067
2019
-
1
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1
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1
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1
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1
1
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-
754304
Zhi
-
Effect of high pressure proce ...
Ananas comosus
J. Food Process Eng.
42
e13146
2019
1
1
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1
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1
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1
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1
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1
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2
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753631
Ramli
Comparative structural analys ...
Ananas comosus
Food Chem.
266
183-191
2018
-
1
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2
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1
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1
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2
2
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1
-
1
1
-
-
-
753642
Meza-Espinoza
Enzyme activity and partial c ...
Bromelia karatas, Bromelia pinguin
Food Sci. Biotechnol.
27
509-517
2018
2
-
-
-
-
-
5
2
-
-
4
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-
2
-
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2
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-
2
4
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6
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2
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8
-
2
2
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2
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5
-
2
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4
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2
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2
4
-
6
-
2
-
8
-
2
2
-
-
-
-
-
-
-
-
754274
Andjaitan
-
Bromelain enzyme from pineapp ...
Ananas comosus
J. Eng. Appl. Sci.
13
3125-3130
2018
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1
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1
1
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753890
Sao Paulo Barretto Miranda
The biochemical characterizat ...
Ananas comosus, Ananas comosus AGB 772
Int. J. Food Sci. Nutr.
68
442-454
2017
-
1
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1
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4
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4
3
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4
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3
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1
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5
3
-
4
-
3
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2
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1
2
-
-
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754238
Das
Destabilization of human insu ...
Ananas comosus
J. Cell. Biochem.
118
4881-4896
2017
-
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4
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1
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3
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1
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1
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1
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1
1
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752429
Mohan
-
Optimisation of bromelain enz ...
Ananas comosus
Am. J. Biochem. Biotechnol.
12
188-195
2016
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1
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1
1
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1
1
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753812
Chakraborty
-
Modeling the inactivation kin ...
Ananas comosus
Innov. Food Sci. Emerg. Technol.
33
10-18
2016
-
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1
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1
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1
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1
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754309
Kaur
Kinetics studies with fruit b ...
Ananas comosus
J. Food Sci. Technol.
52
5954-5960
2015
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3
1
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731210
Arshad
Bromelain: an overview of indu ...
Ananas comosus
Appl. Microbiol. Biotechnol.
98
7283-7297
2014
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1
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1
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4
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1
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717050
Liang
-
Study on the stability of frui ...
Ananas comosus
Adv. Mater. Res.
421
19-22
2012
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2
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1
1
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731843
Corzo
-
Pineapple fruit bromelain affi ...
Ananas comosus
Food Chem.
133
631-635
2012
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4
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731908
Devi
-
Pineapple fruit bromelain and ...
Ananas comosus
Indian J. Agric. Biochem.
25
1-7
2012
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717487
Ferreira
-
Purification of bromelain from ...
Ananas comosus
Chem. Eng. Transact.
24
931-936
2011
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717625
Yin
Preparative purification of br ...
Ananas comosus
Food Chem.
129
925-932
2011
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718411
Gautam
-
Comparative study of extractio ...
Ananas comosus
Thai J. Pharm. Sci.
34
67-76
2010
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710318
Neuteboom
An extended AE-rich N-terminal ...
Ananas comosus
Plant Physiol.
151
515-527
2009
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1
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695660
Shukor
An inhibitive determination me ...
Ananas comosus
Appl. Biochem. Biotechnol.
144
283-291
2008
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2
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1
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2
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2
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6
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2
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665083
Rowan
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Fruit bromelain ...
Ananas comosus
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650803
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Bromelain: biochemistry, pharm ...
Ananas comosus
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2001
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2
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30296
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Purification and characterizat ...
Ananas comosus
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30279
Rowan
Inhibition of cysteine protein ...
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Ota
Reinvestigation of fractionati ...
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30274
Murachi
Bromelain enzymes ...
Ananas comosus
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Yamada
Purification and characterizat ...
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30301
Toro-Goyco
Immunochemical studies on ping ...
Ananas comosus, Bromelia pinguin
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359-366
1976
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30300
Sasaki
Antigenic determinant common t ...
Ananas comosus
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Ota
Fractionation and some propert ...
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30273
Murachi
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Bromelain enzymes ...
Ananas comosus
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