Literature summary for 3.4.22.29 extracted from

Calandria, C.; Irurzun, A.; Barco, A.; Carrasco, L.
Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells (2004), Virus Res., 104, 39-49.

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Protein Variants

Protein Variants	Comment	Organism
additional information	stable expression of enzyme in HeLa cell lines. Expression of enzyme leads to apoptosis, indicated by nuclear fragmentation, DNA breakdown and phosphatidylserine translocation. Enzyme induces the cleavage of poly-ADP-ribose-polymerase, which is blocked by the caspase-3 inhibitor peptide Asp-Glu-Val-Asp	Enterovirus C

Organism

Organism	UniProt	Comment	Textmining
Enterovirus C	-	-	-

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Release 2023.1 (January 2023)