Literature summary for 3.4.22.28 extracted from

Wang, D.; Fang, L.; Wei, D.; Zhang, H.; Luo, R.; Chen, H.; Li, K.; Xiao, S.
Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon (2014), J. Virol., 88, 10252-10258.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nuclear factor-kappaB essential modulator + H2O	Hepatovirus A	the enzyme cleaves the substrate at the Q304 residue, negating its signaling adaptor function	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Hepatovirus A	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nuclear factor-kappaB essential modulator + H2O	the enzyme cleaves the substrate at the Q304 residue, negating its signaling adaptor function	Hepatovirus A	?	-	?

Synonyms

Synonyms	Comment	Organism
3C protease	-	Hepatovirus A
3Cpro	-	Hepatovirus A

General Information

General Information	Comment	Organism
physiological function	the enzyme disrupts nuclear factor-kappaB essential modulator-mediated interferon-beta induction	Hepatovirus A

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Release 2023.1 (January 2023)