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Literature summary for 3.4.22.28 extracted from

  • Lei, X.; Liu, X.; Ma, Y.; Sun, Z.; Yang, Y.; Jin, Q.; He, B.; Wang, J.
    The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses (2010), J. Virol., 84, 8051-8061.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Enterovirus A71
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-
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Synonyms

Synonyms Comment Organism
3C protein
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Enterovirus A71

General Information

General Information Comment Organism
physiological function the 3C protein is able to inhibit virus-induced activation of the interferon-beta promoter. When expressed in mammalian cells, the 3C protein suppresses retinoid acid-inducible gene-I signaling by disruption of the acid-inducible gene-I-interferon promoter-stimulating factor-1 complex and interferon regulatory factor 3 nuclear translocation. Enterovirus 71 infection does not stimulate the expression of interferon-beta, interferon-stimulated genes 54, 56, and tumor necrosis factor-alpha in rhabdomyosarcoma cells. The 3C protein of enterovirus 71 is able to inhibit virus-induced activation of the interferon-beta promoter and inhibits interferon-beta expression by targeting the adaptor retinoid acid-inducible gene I Enterovirus A71