Organism | UniProt | Comment | Textmining |
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Enterovirus A71 | - |
- |
- |
Synonyms | Comment | Organism |
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3C protein | - |
Enterovirus A71 |
General Information | Comment | Organism |
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physiological function | the 3C protein is able to inhibit virus-induced activation of the interferon-beta promoter. When expressed in mammalian cells, the 3C protein suppresses retinoid acid-inducible gene-I signaling by disruption of the acid-inducible gene-I-interferon promoter-stimulating factor-1 complex and interferon regulatory factor 3 nuclear translocation. Enterovirus 71 infection does not stimulate the expression of interferon-beta, interferon-stimulated genes 54, 56, and tumor necrosis factor-alpha in rhabdomyosarcoma cells. The 3C protein of enterovirus 71 is able to inhibit virus-induced activation of the interferon-beta promoter and inhibits interferon-beta expression by targeting the adaptor retinoid acid-inducible gene I | Enterovirus A71 |