Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Human rhinovirus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-aminopyridin-3-yl furan-2-carboxylate | 24% inhibition at 0.001 mM | Human rhinovirus sp. | |
2-carbamoylpyridin-3-yl furan-2-carboxylate | 14% inhibition at 0.001 mM | Human rhinovirus sp. | |
2-oxo-1,2-dihydroquinolin-4-yl furan-2-carboxylate | 98% inhibition at 0.001 mM | Human rhinovirus sp. | |
3-carbamoylphenyl furan-2-carboxylate | 5% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-bromopyridin-3-yl (2E)-3-phenylprop-2-enoate | 63% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-bromopyridin-3-yl 3-phenylpropanoate | 34% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-bromopyridin-3-yl furan-2-carboxylate | most potent inhibitor, 90% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 1H-pyrazole-3-carboxylate | 82% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 2-(diphenylmethyl)-4-ethoxy-1,3-oxazole-5-carboxylate | 5% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 2-benzyl-4-ethoxy-1,3-oxazole-5-carboxylate | 5% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 3-[4-(trifluoromethyl)phenyl]-3H-pyrrole-5-carboxylate | 40% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 4-ethoxy-2-(naphthalen-2-yl)-1,3-oxazole-5-carboxylate | 34% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 4-ethoxy-2-[(E)-2-phenylethenyl]-1,3-oxazole-5-carboxylate | 87% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate | 89% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 5-(4-methylphenyl)furan-2-carboxylate | 79% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 5-(4-nitrophenyl)furan-2-carboxylate | 60% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl 5-phenylfuran-2-carboxylate | 80% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl benzoate | 59% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl furan-2-carboxylate | 87% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl naphthalene-1-carboxylate | 75% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl naphthalene-2-carboxylate | 80% inhibition at 0.001 mM | Human rhinovirus sp. | |
5-chloropyridin-3-yl thiophene-2-carboxylate | 64% inhibition at 0.001 mM | Human rhinovirus sp. | |
pyridin-3-yl furan-2-carboxylate | 8% inhibition at 0.001 mM | Human rhinovirus sp. | |
rupintrivir | AG7088 | Human rhinovirus sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human rhinovirus sp. | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using the IMPACT-CN system | Human rhinovirus sp. |
Synonyms | Comment | Organism |
---|---|---|
3C protease | - |
Human rhinovirus sp. |
3Cpro | - |
Human rhinovirus sp. |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00008 | - |
in 50 mM Tris (pH 7.6), 1 mM EDTA, at 30°C | Human rhinovirus sp. | 5-bromopyridin-3-yl furan-2-carboxylate | |
0.0002 | - |
in 50 mM Tris (pH 7.6), 1 mM EDTA, at 30°C | Human rhinovirus sp. | 2-oxo-1,2-dihydroquinolin-4-yl furan-2-carboxylate | |
0.00029 | - |
in 50 mM Tris (pH 7.6), 1 mM EDTA, at 30°C | Human rhinovirus sp. | 5-chloropyridin-3-yl 1H-pyrazole-3-carboxylate | |
0.00069 | - |
in 50 mM Tris (pH 7.6), 1 mM EDTA, at 30°C | Human rhinovirus sp. | 5-chloropyridin-3-yl 4-ethoxy-2-[(E)-2-phenylethenyl]-1,3-oxazole-5-carboxylate | |
0.00071 | - |
in 50 mM Tris (pH 7.6), 1 mM EDTA, at 30°C | Human rhinovirus sp. | 5-chloropyridin-3-yl naphthalene-2-carboxylate |