Crystallization (Comment) | Organism |
---|---|
crystal structure of AG7088 bound to serotype 2 rhinovirus 3C protease, hanging-drop vapor diffusion method | enterovirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG7088 | inhibitor with potent antiviral activity against multiple human rhinovirus serotypes, highly specific for picornavirus 3C proteases having negligible inhibitory activity against a panel of mammalian cysteine proteases, including cathepsin B, elastase, chymotrypsin, trypsin and calpain | enterovirus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
picornavirus polyprotein + H2O | enterovirus | most maturation cleavages within the precursor polyprotein are mediated by the enzyme | hydrolyzed picornavirus polyprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
enterovirus | - |
human rhinovirus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
picornavirus polyprotein + H2O | most maturation cleavages within the precursor polyprotein are mediated by the enzyme | enterovirus | hydrolyzed picornavirus polyprotein | - |
? |