Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-2-({2-acetyl-1-[3-(dimethylamino)-3-oxopropyl]hydrazinyl}carbonyl)-N-(2-phenylethyl)diazenecarboxamide | potent, irreversible inhibitors with IC50 values in the low micromolar range, probably act by adding the active site thiol to the azo moiety in a Michael fashion to give a covalent complex | enterovirus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hepatitis A virus polyprotein + H2O | Hepatovirus A | the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor | ? | - |
? | |
picornavirus polyprotein + H2O | Hepatovirus A | - |
hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | enterovirus | the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor | hydrolyzed picornavirus polyprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
enterovirus | - |
human rhinovirus | - |
Hepatovirus A | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hepatitis A virus polyprotein + H2O | the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor | Hepatovirus A | ? | - |
? | |
picornavirus polyprotein + H2O | - |
Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | the enzyme is essential for viral maturation and infectivity through the cleavage of polyprotein precursor | enterovirus | hydrolyzed picornavirus polyprotein | - |
? |