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Literature summary for 3.4.22.27 extracted from

  • Aikawa, E.; Aikawa, M.; Libby, P.; Figueiredo, J.L.; Rusanescu, G.; Iwamoto, Y.; Fukuda, D.; Kohler, R.H.; Shi, G.P.; Jaffer, F.A.; Weissleder, R.
    Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease (2009), Circulation, 119, 1785-1794.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.27

Application

Application Comment Organism
drug development increased risk of mortality and morbidity associates with cardiovascular calcification drives the development of new therapeutic strategies to prevent and potentially reverse this process, new therapeutic options may also include selective inhibition of catS Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
apolipoprotein-deficient with minus or plus catS are assigned to chronic renal disease Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cystatin C
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
elastin + H2O Mus musculus
-
 elastin fragments catS generates soluble elastin peptides ?
additional information Mus musculus catS has proinflammatory effects ?
-
 ?
additional information Mus musculus catS is a potent elastolytic protease and accelerates calcification in atherosclerotic mice with chronic renal disease induced by 5/6 nephrectemy ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
smooth muscle
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 osteogenic activity decreases in apolipoprotein-/-/catS-/- mouse aortas with chronic renal disease Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
elastin + H2O
-
 Mus musculus elastin fragments catS generates soluble elastin peptides ?
additional information catS has proinflammatory effects Mus musculus ?
-
 ?
additional information catS is a potent elastolytic protease and accelerates calcification in atherosclerotic mice with chronic renal disease induced by 5/6 nephrectemy Mus musculus ?
-
 ?
additional information cathepsin S substrate Leu-Arg and a poly(ethylene glycol) chain in dendritic arms Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin S
-
 Mus musculus
CatS
-
 Mus musculus