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Literature summary for 3.4.22.27 extracted from

  • Wendt, W.; Luebbert, H.; Stichel, C.C.
    Upregulation of cathepsin S in the aging and pathological nervous system of mice (2008), Brain Res., 1232, 7-20.
    View publication on PubMed

Application

Application Comment Organism
drug development importance of CATS in inflammatory processes, which has generated much interest in the development of CATS inhibitors as immunomodulatory therapeutics for immune disorders such as bronchial asthma, rheumatoid arthritis and psoriasis, CATS may also be an attractive target in neurodegenerative disorders associated with inflammation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsins are primarily involved in general protein turnover, CATS belongs to the cathepsins with a distinct substrate specificity ?
-
?
additional information Mus musculus CATS participates in inflammatory processes accompanying aging and pathologies of the central nervous system ?
-
?
additional information Mus musculus it degrades the invariant chain Ii, which is crucial to the immune response since it acts as an essential step in MHC class II antigen presentation ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice and SOD1-G93A transgenic mice (model of amyotrophic lateral sclerosis)
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the prepeptide of CATS is removed during the passage to the endoplasmic reticulum and the procathepsin undergoes proteolytic processing to the mature enzyme in the lysosomal compartment Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain stem
-
Mus musculus
-
central nervous system
-
Mus musculus
-
cerebellum
-
Mus musculus
-
cerebral cortex
-
Mus musculus
-
corpus callosum
-
Mus musculus
-
hypothalamus
-
Mus musculus
-
microglia
-
Mus musculus
-
phagocyte
-
Mus musculus
-
spinal cord
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
CATS protein expression increases in the cerebral cortex, the cerebellum and the hippocampus, the proform is the predominant enzymatic form in all analyzed age groups Mus musculus
additional information
-
CATS transcript and protein are strongly increased between 3 and 5 months of age in the central nervous system of SOD1-G93A transgenic mice with amyotrophic lateral sclerosis Mus musculus
additional information
-
in a transgenic mouse model of amyotrophic lateral sclerosis expressing mutant superoxide dismutase 1, CATS transcript and protein levels are significantly upregulated in spinal cord and lower brain regions displaying neuronal degeneration Mus musculus
additional information
-
the number of CATS immunopositive cells with glial morphology clearlyincreases in 4-week- and 26-30-month old mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsins are primarily involved in general protein turnover, CATS belongs to the cathepsins with a distinct substrate specificity Mus musculus ?
-
?
additional information CATS participates in inflammatory processes accompanying aging and pathologies of the central nervous system Mus musculus ?
-
?
additional information it degrades the invariant chain Ii, which is crucial to the immune response since it acts as an essential step in MHC class II antigen presentation Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
cathepsin S
-
Mus musculus
CatS
-
Mus musculus