Application | Comment | Organism |
---|---|---|
drug development | importance of CATS in inflammatory processes, which has generated much interest in the development of CATS inhibitors as immunomodulatory therapeutics for immune disorders such as bronchial asthma, rheumatoid arthritis and psoriasis, CATS may also be an attractive target in neurodegenerative disorders associated with inflammation | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | cathepsins are primarily involved in general protein turnover, CATS belongs to the cathepsins with a distinct substrate specificity | ? | - |
? | |
additional information | Mus musculus | CATS participates in inflammatory processes accompanying aging and pathologies of the central nervous system | ? | - |
? | |
additional information | Mus musculus | it degrades the invariant chain Ii, which is crucial to the immune response since it acts as an essential step in MHC class II antigen presentation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice and SOD1-G93A transgenic mice (model of amyotrophic lateral sclerosis) | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the prepeptide of CATS is removed during the passage to the endoplasmic reticulum and the procathepsin undergoes proteolytic processing to the mature enzyme in the lysosomal compartment | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain stem | - |
Mus musculus | - |
central nervous system | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
cerebral cortex | - |
Mus musculus | - |
corpus callosum | - |
Mus musculus | - |
hypothalamus | - |
Mus musculus | - |
microglia | - |
Mus musculus | - |
phagocyte | - |
Mus musculus | - |
spinal cord | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
CATS protein expression increases in the cerebral cortex, the cerebellum and the hippocampus, the proform is the predominant enzymatic form in all analyzed age groups | Mus musculus |
additional information | - |
CATS transcript and protein are strongly increased between 3 and 5 months of age in the central nervous system of SOD1-G93A transgenic mice with amyotrophic lateral sclerosis | Mus musculus |
additional information | - |
in a transgenic mouse model of amyotrophic lateral sclerosis expressing mutant superoxide dismutase 1, CATS transcript and protein levels are significantly upregulated in spinal cord and lower brain regions displaying neuronal degeneration | Mus musculus |
additional information | - |
the number of CATS immunopositive cells with glial morphology clearlyincreases in 4-week- and 26-30-month old mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsins are primarily involved in general protein turnover, CATS belongs to the cathepsins with a distinct substrate specificity | Mus musculus | ? | - |
? | |
additional information | CATS participates in inflammatory processes accompanying aging and pathologies of the central nervous system | Mus musculus | ? | - |
? | |
additional information | it degrades the invariant chain Ii, which is crucial to the immune response since it acts as an essential step in MHC class II antigen presentation | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin S | - |
Mus musculus |
CatS | - |
Mus musculus |