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Literature summary for 3.4.22.27 extracted from

  • Cheng, F.C.; Feng, J.J.; Chen, K.H.; Imanishi, H.; Fujishima, M.; Takekoshi, H.; Naoki, Y.; Shimoda, M.
    Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases (2008), Int. J. Food Sci. Nutr., 60 Suppl 1, 89-98.
    View publication on PubMed
Search for more literature for 3.4.22.27

Application

Application Comment Organism
drug development enzyme may be a potential target in rheumatoid arthritis and obesity with its associated cardiovascular risks Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
human recombinant cathepsin S expressed in a murine myeloma NS0 cells is used Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Chlorella powder
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme mediates degradation of the MHC class II invariant chain and participates in antigen processing ?
-
 ?
additional information Homo sapiens protease is implicated in the development of atherosclerotic lesions in both animal ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-
culture condition:antigen-presenting cell
-
 Homo sapiens
-
inflammatory cell
-
 Homo sapiens
-
lymph node
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme mediates degradation of the MHC class II invariant chain and participates in antigen processing Homo sapiens ?
-
 ?
additional information protease is implicated in the development of atherosclerotic lesions in both animal Homo sapiens ?
-
 ?
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Z-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin S
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 chlorella powder inhibits peptidase cathepsin S in a dose-concentration manner with 50% inhibitory concentration of 3.46 mg/l Homo sapiens Chlorella powder